杨轶，博士、副教授
2010年9月-2017年2月，在韩国顺天国立大学药学院、韩国地衣研究中心进行抗肿瘤活性的新药筛选以及分子机制研究，获得理学硕士和博士学位。2017年3月-2018年8月，在韩国全南国立大学医学院基因控制医学研究中心（MRC）从事博士后研究。2018年9月-2020年2月，在韩国全南国立大学担任学术研究教授。2020年7月至今，williamhill中文欢迎您医学院工作，获得省级人才称号。以第一作者发表SCI论文7篇，申请国际专利4项，曾主持韩国国家研究基金会（NFR）青年基金1项，肿瘤微环境与免疫治疗湖北省重点实验室开放基金1项，获得williamhill中文欢迎您高层次人才启动基金1项。
研究方向
主要从事地衣相关天然化学产物的抗肿瘤干细胞发生、侵袭转移以及诱导肿瘤细胞凋亡等靶向抗肿瘤活性的药物筛选发现以及机制研究。
科研课题基金
韩国国家研究基金会（NRF）理工科个人基础研究支持项目2018R1D1A1B07042608； 抗肿瘤活性的地衣次生代谢产物的鉴定及机制分析（2018.6- 2021.5）
重点实验室开放基金2021KZL02;抗结肠肿瘤干细胞发生的新药筛选及机制研究（2021.7-2023.7）
williamhill中文欢迎您高层次人才启动基金 (2021.5-2024.4)
发表论文
Yang, Y.; Nguyen, T.T.; Pereira, I.; Hur, J.-S.; Kim, H. Lichen Secondary Metabolite Physciosporin Decreases the Stemness Potential of Colorectal Cancer Cells. Biomolecules 2019, 9, 797.
Gamage, C.D., Park, S.-Y., Yang, Y., Zhou, R., Taş, İ., Bae, W.K., Kim, K.K., Shim, J.-H., Kim, E., Yoon, G., 2019. Deoxypodophyllotoxin Exerts Anti-Cancer Effects on Colorectal Cancer Cells Through Induction of Apoptosis and Suppression of Tumorigenesis. International journal of molecular sciences 20, 2612.
Zhou, R., Yang, Y., Park, S.-Y., Seo, Y.-W., Jung, S.-C., Kim, K.K., Kim, K., Kim, H., 2019. p300/CBP-associated factor promotes autophagic degradation of δ-catenin through acetylation and decreases prostate cancer tumorigenicity. Scientific reports 9, 3351.
Taş, İ., Han, J., Park, S.-Y., Yang, Y., Zhou, R., Gamage, C.D., Van Nguyen, T., Lee, J.-Y., Choi, Y.J., Yu, Y.H., 2019. Physciosporin suppresses the proliferation, motility and tumourigenesis of colorectal cancer cells. Phytomedicine 56, 10-20.
Yang, Y., Bhosle, S., Yu, Y., Park, S.-Y., Zhou, R., Taş, İ., Gamage, C., Kim, K., Pereira, I., Hur, J.-S., 2018. Tumidulin, a Lichen Secondary Metabolite, Decreases the Stemness Potential of Colorectal Cancer Cells. Molecules 23, 2968.
Yang, Y., Bae, W.K., Nam, S.-J., Jeong, M.-H., Zhou, R., Park, S.-Y., Taş, İ., Hwang, Y.-H., Park, M.-S., Chung, I.J., 2018. Acetonic extracts of the endolichenic fungus EL002332 isolated from Endocarpon pusillum exhibits anticancer activity in human gastric cancer cells. Phytomedicine 40, 106-115.
Yang, Y., Bae, W.K., Lee, J.-Y., Choi, Y.J., Lee, K.H., Park, M.-S., Yu, Y.H., Park, S.-Y., Zhou, R., Taş, İ., 2018. Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer. Scientific reports 8, 16234.
Zhou, R., Yang, Y., Park, S.-Y., Nguyen, T.T., Seo, Y.-W., Lee, K.H., Lee, J.H., Kim, K.K., Hur, J.-S., Kim, H., 2017. The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis. Scientific reports 7, 8136.
Yang, Y., Zhou, R., Park, S.-Y., Back, K., Bae, W., Kim, K., Kim, H., 2017. 2-Hydroxymelatonin, a Predominant Hydroxylated Melatonin Metabolite in Plants, Shows Antitumor Activity against Human Colorectal Cancer Cells. Molecules 22, 453.
Yang, Y., Nguyen, T.T., Jeong, M.-H., Crişan, F., Yu, Y.H., Ha, H.-H., Choi, K.H., Jeong, H.G., Jeong, T.C., Lee, K.Y., 2016. Inhibitory activity of (+)-usnic acid against non-small cell lung cancer cell motility. PloS one 11, e0146575.
Yang, Y., Park, S.-Y., Nguyen, T.T., Yu, Y.H., Van Nguyen, T., Sun, E.G., Udeni, J., Jeong, M.-H., Pereira, I., Moon, C., 2015. Lichen secondary metabolite, physciosporin, inhibits lung cancer cell motility. PloS one 10, e0137889.
Nguyen, T.T., Yoon, S., Yang, Y., Lee, H.-B., Oh, S., Jeong, M.-H., Kim, J.-J., Yee, S.-T., Crişan, F., Moon, C., 2014. Lichen secondary metabolites in Flavocetraria cucullata exhibit anti-cancer effects on human cancer cells through the induction of apoptosis and suppression of tumorigenic potentials. PloS one 9, e111575.
